Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mic...

Molecular mobility is important for interactions of biofunctional polymers with target molecules. Monomer structures synthetic are usually selected based on their compatibility polymerization systems, whereas the influence monomer interaction molecules hardly considered. In this report, we evaluate correlation between glycopolymers and concanavalin A (ConA) respect to molecular mobility. Two ty...

A gold nanoparticle-based competitive colorimetric assay uses the ensemble of Concanavalin (ConA) and mannopyranoside-encapsulated gold nanoparticles (Man-GNPs) to identify the binding partners for ConA and the binding constants are determined based on the wavelength shifts.

The interaction of a mannose-substituted poly(para phenyleneethynylene) (mPPE) with a lectin, Concanavalin A (ConA), is reported; the ConA causes fluorescence quenching of the mPPE with a K(SV) of 5.6 x 10(5).

to evaluate the effect of supplemental vitamin c (vc) levels on performance and immune response of broiler chicks, 300 day-old ross male broiler chicks were allocated to a completly randomized design of 5 treatments(500 and 1000 ppm in diet, 500 and 1000 ppm in drinking water and control). immunity was assessed as antibody production against infectious bronchitis virus (ibv) and newcastle disea...

Rat T-kininogen has been separated into two molecular variants by affinity chromatography on concanavalin A (ConA): a ConA-reactive (ConA+) and a ConA-non-reactive (ConA-) fraction, from which carbohydrate chains were quantitatively released by hydrazinolysis. On the basis of high-resolution 400 MHz 1H-n.m.r. spectroscopy of the re-N-acetylated hydrazinolysates, the carbohydrate structures of t...

Abstract We report a novel glycan array architecture that binds the mannose‐specific binding protein, concanavalin A (ConA), with sub‐femtomolar avidity. new radical photopolymerization developed specifically for this application combines grafted‐from thiol–(meth)acrylate polymerization thiol–ene chemistry to graft glycans growing polymer brushes. The propagation of brushes was studied by carry...

Background & AimsThe circadian rhythms play significant roles in immune responses and many inflammatory processes liver diseases are associated with malfunctioning molecular clocks. However, the significance of clock autoimmune hepatitis (AIH) which is characterized by immune-mediated hepatocyte destruction extensive cytokine production remains unclear.MethodsWe tested difference susceptibility...

Neural induction and differentiation has been studied using Concanavalin A, cyclic AMP, tunicamycin and calcium ionophore A 23187. Competent ectoderm of Xenopus laevis treated with Concanavalin A differentiates into neural (archencephalic) structures. Binding studies with gold-labelled ConA indicate that the superficial ectodermal layer contains fewer ConA-sensitive sites (alpha-D-mannoside and...

Structure-energy relationships for a small group of pyranose and septanose mono-saccharide ligands are developed for binding to Concanavalin A (ConA). The affinity of ConA for methyl "manno"β-septanoside 7 was found to be higher than any of the previously reported mono-septanoside ligands. Isothermal titration calorimetry (ITC) in conjunction with docking simulations and quantum mechanics/molec...